RISK FACTORS, CONSOLIDATED DISEASES, CLINICAL AND IMMUNOLOGICAL FEATURES IN EXCERNSATION OF GASTRIC AND DUODENAL ULCER IN PATIENTS IN THE DISPENSARY GROUP

Abstract

An analysis of modern domestic and foreign medical literature shows that, despite the progress achieved in recent years, peptic ulcer of the stomach and duodenum does not lose its relevance [2, 8, 10, 12]. World statistics show that peptic ulcer disease remains one of the most common diseases of internal organs. In Russia, the prevalence of this pathology among the entire population is about 12%, and the results of pathological studies give higher figures - 28%, which may indicate a latent course of the disease in many patients [1]. It has been proven that the leading role in the etiopathogenesis of peptic ulcer disease is currently given to H. pylori infection. However, despite the introduction of eradication regimens into treatment standards, the problem of H. pylori-associated peptic ulcer disease cannot be considered solved. Thus, according to a number of Russian authors: Avakimyan V.A et al., 2008 [3, 4], Shaposhnikova V.I., 2008. [7], Povalyaeva A.B., 2009 [3], Stupina V.A., 2011. [4], in Russia there is an increase in complications of ulcerative disease, such as bleeding and perforation. The mortality rate from ulcer bleeding remains high, up to 15%, and has remained virtually unchanged over the past 20 years [6, 9, 14]. Despite the undeniable success of introducing various H. pylori eradication therapy regimens into clinical practice, the expected reduction in the frequency of relapses of peptic ulcer disease in the country has not occurred [2]. It should be noted that there are no Russian multicenter studies of the prevalence of H. pylori, which makes it difficult to assess both the prevalence of this infection and its dynamics over time [1]. This is especially important due to the importance of these indicators, primarily for planning preventive work and morbidity control. The relevance of studying peptic ulcer disease is determined by the fact that this disease has not only medical, but also socio-economic significance, which emphasizes the need to improve treatment tactics for this group of patients [9].